As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...) test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans. (shrink)

_Early Psychoanalytic Religious Writings_ presents, in one edited volume, many of the foundational writings in the psychoanalytic study of religion. These translated works by Abraham, Fromm, Pfister, and others, complement Freud’s seminal contributions and provide a unique window into the origins of psychoanalytic thinking.

At Epistles 2.2.87–9 Horace introduces an argument against writing poetry based on the unpleasant mutual admiration required in poetic society with an anecdote about an orator and a jurisconsult: †frater erat Romae† consulti rhetor, ut alter alterius sermone meros audiret honores, Gracchus ut hic illi, foret huic ut Mucius ille.

At Epistles 2.2.87–9 Horace introduces an argument against writing poetry based on the unpleasant mutual admiration required in poetic society with an anecdote about an orator and a jurisconsult: †frater erat Romae† consulti rhetor, ut alter alterius sermone meros audiret honores, Gracchus ut hic illi, foret huic ut Mucius ille.

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

The excellent quality and depth of the various essays make [the book] an invaluable resource....It is likely to become essential reading in its field.—CHOICE.

To begin with, there is a conceptual necessity implied in the very concept of cause itself, and in all concepts that have a causal element; and this definitional "must," far from being conventional or arbitrary, reflects the natural necessity of those physical systems which in fact constitute the nature of our universe. The conceptual necessity of the concept of cause can be pointed up in the following way. Assume that we have good reason for saying at to that f, g, (...) h, and i are jointly sufficient to E and hence C of E. What would we say at t1 if f, g, h, and i occurred but not E? We would clearly not say then, or ever, that while ordinarily these conditions are jointly sufficient for E, this time they were not; rather we would say that somehow we were mistaken in thinking that f, g, h, and i at t1 were identical with f, g, h, and i at t0. We might have been mistaken in either of two ways. We might have mis-identified one of the conditions at t1, erroneously thinking, say, that p was an f; or one or more of the conditions might have had its nature altered, losing some capacity or power it once had. In either case, we would withdraw the claim at t1 that C was the cause of E. Since we would withdraw the use of C at t1 and would never admit that f, g, h, and i at any t, if genuine instances of f, g, h, and i, would not produce E, we are clearly using C in such a way that actually producing E is part of its meaning. On the assumption that the conditions are genuinely the same, it follows, so to speak, from the principle of identity that they must produce the same effect. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

There has been much first-rate work done in recent years both by way of criticizing Humean assumptions and explicating alter native concepts of causal explanation and non-logical necessity. Roderick Chisholm early showed the inadequacies of neo-Humean views of explanation in his articles on counterfactual inference, and C. J. Ducasse, Sterling Lamprecht, William Kneale, Nicholas Maxwell, Richard Taylor, G. E. M. Anscombe, P. T. Geach, Milton Fisk, Baruch Brody, Peter Alexander, R. Harré, and William Wallace, among others, have articulated interesting alternative (...) views to the Humean ones they have so trenchantly criticized. We will be concerned with the recent work of Harré and Wallace in this study. Harré has not only launched a fresh attack but has also presented what is probably the most fully developed neorealistic [[sic]] alternative. Wallace’s work is basically historical but has an intentional systematic import also. The books of the two authors are mutually supportive. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Paul Oskar Kristeller 1905–1999Edward P. MahoneyPaul Oskar Kristeller was without doubt one of the most productive and accomplished scholars of this century. He received an excellent education in the classics at the Mommsen-Gymnasium in his native Berlin before going to the University of Heidelberg in 1923. There he pursued studies in a wide range of subjects, including medieval history, German literature, physics, and art history. The philosophy professors who (...) much influenced him both at Heidelberg and at Freiburg and Marburg were Ernst Hoffman, Karl Jaspers, Richard Kroner, and Martin Heidegger. In 1929 he received his doctorate from Heidelberg for his dissertation Der Begriff der Seele in der Ethik des Plotin, which was directed by Hoffman and published at Tübingen the same year. He then went to Berlin, where he engaged in formal studies in classical philology before going to Freiburg to do postgraduate work in philosophy with Heidegger during the years 1931 to 1933. Heidegger approved a study of Marsilio Ficino as Kristeller’s Habili-tationschrift and helped him to secure a fellowship enabling him to do research on Ficino and to begin writing. After visiting Italy during this period and taking into account the changed political scene in Germany, Kristeller decided in 1934 to move to Italy permanently. He taught in Florence in a high school for German Jewish students until he secured in 1935, with the help of Giovanni Gentile, a lectureship in German at the Scuola Superiore and the University of Pisa. He maintained throughout his academic career a personal and warm attachment to the Scuola Superiore. Moreover, he enjoyed throughout his subsequent career a warm and personal friendship with various Italian scholars that was first developed during his Italian stay in the thirties.While still in Italy, Kristeller completed his book on Ficino in 1937; he prepared an Italian version the next year. However, both the German and Italian versions would be published only years later. During this period he also engaged in manuscript studies in the major Italian cities, searching in particular for Ficino manuscripts. The result of these labors was his two-volume work, Supplementum Ficinianum: Marsilii Ficini Philosophi Platonici Opuscula Inedita et Dispersa, which was published by the Scuola Normale in 1937. He considered his “teachers” in manuscript studies to be Giovanni Cardinal Mercati, Monsignor Auguste Pelzer, and Ludwig Bertalot. Giovanni Gentile aided the publication of Kristeller’s Supplementum Ficinianum and subsequently helped him to emigrate to the United States. Kristeller always maintained a loyalty to Gentile and felt gratitude to him for extending him such help.In 1938 Kristeller lost his position at Pisa because of the Fascist anti-Semitic laws, but he was permitted to go to Rome where he assisted Bertalot in manuscript research at the Vatican library. Through the intervention of Roland H. Bainton, Dean P. Lockwood, Dom Anselm Strittmater, O.S.B., and other American [End Page 758] friends Kristeller was able to leave for the United States. He arrived at New York in February 1939 and spent the Spring term at Yale University. He was given an adjunct position at Columbia University for the fall term, holding the rank of Associate until 1948, when he was made an Associate Professor of Philosophy. By that time he had established himself as a major force in the development of Renaissance studies in the United States. His book on Ficino was translated into English as The Philosophy of Marsilio Ficino and published in 1943 by the Columbia University Press. The Italian version was published at Florence in 1953; a revised edition, containing a new bibliography that had been brought up to date, appeared in 1988.Kristeller published a large number of articles on a wide range of topics, establishing himself as a major interpreter of the significance of Renaissance humanism as well as a leading authority not only on Ficino and Renaissance Platonism but also on Pietro Pomponazzi and Renaissance Aristotelianism. He developed at Columbia bonds of friendship with Ernest A. Moody and John Herman Randall, Jr., both of whom had strong interests in late-medieval Aristotelianism. With Randall and Ernst Cassirer he prepared what would become a bestseller, the Renaissance Philosophy of Man: Selections... (shrink)

Researchers, including Boyer & Petersen (B&P), commonly use experimental economic studies to draw their conclusions. These studies conventionally strip away context and present participants only with abstract rules. Because context is a strictly necessary component of the decision-making process, it is not clear that inferences about high-level folk psychological concepts (e.g., rationality) can be drawn from decontextualized economic games.

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 273 Verene, Donald Phillip. Vico's Science of Imagination. Ithaca, New York: Cornell University Press, 1981, Pp. 227. $19.5o. In Chapter 1 (Introduction: Vico's Originality), Verene announces two principal concerns, a two-fold approach, and the predominant contention of his study.. 1. Principal concerns: "to consider the philosophical truth of Vico's ideas themselves, rather than to examine their historical character" (p. 19); to consider "the importance of Vico's conception (...) of barbarism for understanding present society" (p. 28). 2. Two-fold approach: "to interpret the central theses of Vico's thought" from the inside in the spirit of the whole and, at the same time, "to develop the problems of Vico's philosophy themselves" (pp. 19--21 ). 3. Predominant contention: "that Vico's ideas constitute a philosophy of recollective universals which generates philosophical understanding fronl the image, not the rational category. This approach regards imagination as a method of pfiilosophical thought" (p. 19) and the imaginative universal as "a key to his conception of knowledge" (p. 67). Vico's philosophy is depicted and characterized by Verene as fi)llows. Beginning with the imagination (fantasia) as an original and independent power of mind, Vico builds his philosophy on the image, the imaginative universal, thereby creating a position outside Western philosophy as traditionally understood. His New Science is a process of recollective fantasia, a kind of memory, and the system built constitutes a system of memory for all of human reality. By means of his concept of memory, Vico works his way back to the world of original thought, the mythicopoeticfantasia of the first men. His discovery of the imaginative universal as their way of thinking and their kind of knowledge establishes a new genetic origin for philosophical thought. Recollective fantasia constitutes the subject-matter and form of Vico's science itself', i.e., the term designates a type of nlemory through which the New Science is acconlplished as well as the type of thought from which it must be understood. "The New Science is a metaphysical fable, h creates a vera narratio of the recollectire imagination. The storia ideale eterna is an ideal trnth, but not an a priori or fictional one. As the master image of the recollective mind, it precisely contains all of the human event. Metaphysical truth, achieved through the exercise of.[antasia.., is generated out of the mind itself.., as images that actually contain the providential structure of reality" (p. 125). Vico's per|ornlative science "is man's true production of a knowledge of" his own nature" (p. 133). "The proof of the science is found through the reader making it for himself" (p. 156). What is the "recollective imaginative universal"? (a term coined by Verene) as distinguished from the universale fantastico? Vico identifies the latter quite simply. Poetic imagination, he tells us, was active in the first men who, "not being able to form intelligible class concepts of things, had a natural need to create poetic characters ; that is, imaginative class concepts or universals, to which, as to certain models or ideal portraits, to reduce all the particular species that resembled them." (The New Science of Giambattista Vico, trans. Thomas Goddard Bergin and Max Harold Fisch. Cornell University Press, 1968; orig. pub. 1948, w ) Thus in the theological age, 274 HISTORY OF PHILOSOPHY "Jove was born naturally in poetry as a divine character or imaginative universal, to which everything having to do with the auspices was referred by all the ancient gentile nations, which must therefore all have been poetic by nature" (9 381). In the age of heroes, Achilles embodies the idea of valor common to all strong men and Ulysses the idea of prudence common to all wise men (9 403). The myths, fables, and allegories brought to birth by poetic imagination were true stories for their makers. Imaginative universals or genera, "as the human mind later learned to abstract forms and properties from subjects, passed over into intelligible genera, which prepared the way for philosophers.... " (9 934)- Abstracting, categorizing, and predicating on the basis of properties in common, the philosophers in their intelligible class concepts no hmger think in the same manner as the first men did... (shrink)

Troubadour of truth, by R. E. Brennan.--Reflections on necessity and contingency, by Jacques Maritain.--Intellectual cognition, by Rudolf Allers.--The problem of truth, J. K. Ryan.--The ontolgical roots of Thomism, by Hilary Carpeuter.--The role of habitus in the Thomistic metaphysics of potency and act, by V. J. Bourke.--The nature of the angels, by J. O. Riedl.--The dilemma of being and unity, by A. C. Pegis.--Prudence, the incommunicable wisdom, by C. J. O'Neil.--A question about law, by M. J. Adler.--The economic philosophy of Aquinas, (...) by J. A. Ryan.--Beyond the crisis of liberalism, by Y. R. Simon.--The fate of representative government, by Walter Farrell.--The Thomistic concept of education, by R. J. Slavin.--The perennial theme of beauty, by Immanuel Chapman.--Epilogue, by H. T. Schwartz.--Bibliography (p.[363]-419). (shrink)

This book presents Robert S. Hartman’s formal theory of value and critically examines many other twentieth century value theorists in its light, including A.J. Ayer, Kurt Baier, Brand Blanshard, Paul Edwards, Albert Einstein, William K. Frankena, R.M. Hare, Nicolai Hartmann, Martin Heidegger, G.E. Moore, P.H. Nowell-Smith, Jose Ortega y Gasset, Charles Stevenson, Paul W. Taylor, Stephen E. Toulmin, and J.O. Urmson.

This collection of 11 studies provides a new discussion of Lucretius' History of the Human Mankind and of other topics (Lucretius' explanation of sleep, dreams and optical illusions) in relationship to other philosophical and scientific doctrines of Antiquity.

This collection of 11 studies provides a new discussion of Lucretius' History of the Human Mankind and of other topics (Lucretius' explanation of sleep, dreams and optical illusions) in relationship to other philosophical and scientific doctrines of Antiquity.

Keith Thomas: Gerald Edward Aylmer, 1926-2000 Adrian Hollis: William Spencer Barrett, 1914-2001 Bruce Williams: Charles Frederick Carter, 1919-2002 Malcolm Mackintosh: John Erickson, 1929-2002 J. H .R. Davis: Raymond William Firth, 1901-2002 F. M. L. Thompson: Hrothgar John Habakkuk, 1915-2002 A. W. Price: Richard Mervyn Hare, 1919-2002 Hugh Lloyd-Jones: Geoffrey Stephen Kirk, 1921-2003 Michael Lapidge and Peter Matthews: Vivien Anne Law, 1954-2002 Ann Moss: John Lough, 1913-2000 Terence Cave: Ian Dalrymple McFarlane, 1915-2002 Ludwig Paul: David Neil MacKenzie, 1926-2001 Peter Birks: John (...) Kieran Barry Moylan Nicholas, 1919-2002 Jonathan Shepard: Dimitri Dimitrievich Obolensky, 1918-2001 David Cannadine: John Harold Plumb, 1911-2001 Daniel Waley: Nicolai Rubinstein, 1911-2002 Ian Wood: John Michael Wallace-Hadrill, 1916-1985 R. G. M. Nisbet: William Smith Watt, 1913-2002 G. W. Bernard: Richard Bruce Wernham, 1906-1999. (shrink)

A scholarly edition of a work by David Hume. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

This article explores the influence of Stoicism and religion on Adam Smith. While other commentators have argued either that the main influence on Smith was Stoicism or that it was religion, the two influences have not been explicitly linked. In this article I attempt to make such a link, arguing that Smith can be seen as belonging to the strand of Christian Stoicism chiefly associated with his teacher, Francis Hutcheson. Finally, some comments are made about the implications of this interpretation (...) for current understanding of the work of Adam Smith. (shrink)

This collection introduces readers to some of the most respected Pre-Socratic scholarship of the twentieth century. It includes translations of important works from European scholars that were previously unavailable in English and incorporates the major topics and approaches of contemporary scholarship. Here is an essential book for students and scholars alike. "Students of the Pre-Socratics must be grateful to Mourelatos and his publishers for making these essays available to a wider public."--T. H. Irwin, American Journal of Philology "Mourelatos is a (...) superb editor, and teaching Pre-Socratics in the future with this collection on the reading list will not only be easier but also better."--Jorgen Mejer, The Classical World "The editor has done his work judiciously. It would be difficult to devise a better balance between different parts of the subject."--Edward Hussey, Archives internationales d'histoire des sciences "[This book] will undoubtedly become an indispensable aid for beginning and advanced students of the Pre-Socratics."--David E. Hahm, Isis. (shrink)